发明名称 |
SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: CHIMERIC SELEX |
摘要 |
Methods are disclosed for producing chimeric nucleic acid molecules with two or more functionalities. A chimeric library is generated in which individual chimeric molecules combine the functions or characteristics of two or more parent libraries, each parent library having been selected through the SELEX procedure for a specific function or feature. The chimeric molecules of this invention are useful in a variety of ways, including having improved affinities for a target molecule, enhancing assembly of multi-component molecules, and promoting reactions between two molecules.
|
申请公布号 |
WO9604403(A1) |
申请公布日期 |
1996.02.15 |
申请号 |
WO1995US09446 |
申请日期 |
1995.07.26 |
申请人 |
UNIVERSITY RESEARCH CORPORATION;NEXSTAR PHARMACEUTICALS, INC.;BURKE, DONALD;TARASOW, TED;EATON, BRUCE;GOLD, LARRY |
发明人 |
BURKE, DONALD;TARASOW, TED;EATON, BRUCE;GOLD, LARRY |
分类号 |
A61K31/70;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07H21/02;C07H21/04;C07K5/00;C07K14/00;C12N9/12;C12N15/10;C12N15/115;C12P19/34;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76;(IPC1-7):C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|