发明名称 |
Methods of prolonged suppression of humoral immunity |
摘要 |
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged. |
申请公布号 |
ZA9406765(B) |
申请公布日期 |
1996.02.15 |
申请号 |
ZA19940006765 |
申请日期 |
1994.09.02 |
申请人 |
TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
RANDOLPH J NOELLE;TERESA M FOY |
分类号 |
A61K35/14;A61K35/28;A61K38/00;A61K38/17;A61P37/06;C07K14/705;C07K16/28;C07K19/00;G01N33/68 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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