| 摘要 |
The invention concerns pharmaceutical compositions containing as the active substance estra-1,3,5(10)-triene derivatives with an R-SO2-O- group on the 3 C-atom, R being an R<1>R<2>N- group in which R<1> and R<2>, independently of each other, are a hydrogen atom, an alkyl group with 1 to 5 C-atoms or, together with the N-atom, a polymethyleneimino group with 4 to 6 C-atoms or a morpholino group. The compounds described are suitable for use in hormonal contraception and in climacteric hormone-replacement therapy (HRT), as well as in the treatment of gynaecological and andrological conditions. The compounds described thus only have a low hepatic oestrogenicity.
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| 申请人 |
JENAPHARM GMBH, 07745 JENA, DE |
发明人 |
ELGER, WALTER, DR., 14195 BERLIN, DE;SCHWARZ, SIGFRID, PROF. DR., 07743 BERLIN, DE;SIEMANN, HANS-JOACHIM, DR., 07747 JENA, (VERSTORBEN), DE;REDDERSEN, GUDRUN, 07749 JENA, DE;SCHNEIDER, BIRGITT, 07745 JENA, DE |
