Anti-helicobacter heterocyclic derivatives of azolones

摘要

The invention is concerned with the compounds having the formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is pyridinyl optionally substituted with up to two C1-4alkyl groups; di(C1-4alkyl) hydroxypyridinyl; di(C1-4alkyl)C1-4alkyloxypyridinyl; pyridazinyl optionally substituted with C1-4alkyloxy; pyrimidinyl optionally substituted with hydroxy or C1-4alkyloxy; thiazolyl optionally substituted with C1-4alkyl; thiadiazolyl optionally substituted with C1-4alkyl; benzoxazolyl or benzothiazolyl; or R6 is pyrazinyl or pyridazinyl substituted with C1-4alkyl; Z is C=O or CHOH; and is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.