| 摘要 |
<p>The present invention provides a method of assessing an individual's predisposition to low or high bone density and/or risk of fracture comprising assessing the vitamin D receptor genotype of the individual by haplotype analysis. Preferably the genotype of the individual is assessed by haplotype analysis by assessing the genotype for the polymorphic restriction endonuclease sites for Bsm-1, Apa-1 and Taq-1 in the combinations of Bsm-1 and Apa-1, or Taq-1 and Apa-1, or Bsm-1 and Taq-1, or Bsm-1, Apa-1 and Taq-1.</p> |
