摘要 |
The present invention relates to compounds of formula (I), wherein A is an optionally substituted phenyl, naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring carbon atoms or a bicyclic ring system, provided that the -CH(R<3>)N(R<2>)B-R<1> and -OCH(R<4>-)-D linking groups are positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the -OCHR<4> - linking group (and therefore in the 3-position relative to the -CHR<3>NR<2>- linking group) is not substituted; B is an optionally substituted ring system; D is an optionally substituted ring system; R<1> is a variety of group as defined in the description; R<2> is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenylC1-3alkyl or 5- or 6-membered heteroarylC1-3alkyl; R<3> is hydrogen or C1-4alkyl; R<4> is hydrogen or C1-4alkyl; and N-oxides of NR<2> where chemically possible; and S-oxides of sulphur containing rings were chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof. Process for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
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申请人 |
ZENECA LIMITED;BREAULT, GLORIA, ANNE;OLDFIELD, JOHN;TUCKER, HOWARD;WARNER, PETER |
发明人 |
BREAULT, GLORIA, ANNE;OLDFIELD, JOHN;TUCKER, HOWARD;WARNER, PETER |