3-CARBOXYSTEROIDS WITH A FLUORINATED SIDE CHAIN

摘要

The present invention provides a compound of formula (I), wherein A is a bond or a straight or branched C1-C6 alkylene chain; W is a group -R1, -OR2, -NR3R4 or (a) wherein: Y is oxygen or sulphur; R1, R2 and R4 are: a C1-C10 alkyl group, substituted by one or more fluorine atoms; or a C6-C15 cycloalkylalkyl group, substituted by one or more fluorine atoms; or an aryl group, substituted by one or more fluorine atoms; or a C7-C15 arylalkyl group, substituted by one or more fluorine atoms; R3 and each of R5, R6, and R7, independently, are hydrogen, or a C1-C10 alkyl group, unsubstituted or substituted by one or more fluorine atoms, or a C6-C15 cycloalkylalkyl group, unsubstituted or substituted by one or more fluorine atoms; or an aryl group, insubstituted or substituted by one or more fluorine atoms; or a C7-C15 arylalkyl group, unsubstituted or substituted by one or more fluorine atoms; provided that when W is a group (b) at least one of R5, R6 and R7 is different from hydrogen and contains at least one fluorine atom, and the pharmaceutically acceptable salts thereof. The compounds of formula (I) and their salts are 5 alpha -reductase inhibitors.