| 摘要 |
<p>The present invention relates, in general, to human brain specific kinase, hBsk. In particular, the present invention relates to nucleic acid molecules coding for hBsk; hBsk polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to hBsk; hybridomas containing the antibodies; nucleic acid probes for the detection of hBsk nucleic acid; a method of detecting hBsk nucleic acid or polypeptide in a sample; and kits containing nucleic acid probes or antibodies. This invention further relates to bioassays using the nucleic acid sequence, receptor protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with neurodegenerative disease. Therapeutic uses for the hBsk receptor-like tyrosine kinase are also provided. This invention also relates to the ligand for the hBsk receptor, and diagnostic and therapeutic uses for the hBsk ligand.</p> |
