发明名称 |
CLONING AND EXPRESSION OF AN ACETYLCHOLINE-GATED ION CHANNEL RECEPTOR SUBUNIT |
摘要 |
The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
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申请公布号 |
WO9603504(A1) |
申请公布日期 |
1996.02.08 |
申请号 |
WO1995US09104 |
申请日期 |
1995.07.18 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
ELGOYHEN, ANA, BELEN;JOHNSON, DAVID, S.;BOULTER, JAMES, RICHARD;HEINEMANN, STEPHEN, FOX |
分类号 |
A01K67/027;C07K14/705;C07K16/28;C12N5/10;C12N15/09;C12N15/12;C12P21/08;C12Q1/68;G01N33/53;(IPC1-7):C12N15/12;C12N15/85;C12Q1/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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