| 摘要 |
PCT No. PCT/GB95/00658 Sec. 371 Date Nov. 20, 1996 Sec. 102(e) Date Nov. 20, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/25718 PCT Pub. Date Sep. 28, 1995The present invention relates to compounds of general formula (I) <IMAGE> (I) where R1 and R2, which may be the same or different, each represent a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic or aryl group or together with the nitrogen atom to which they are attached form a heterocyclic group; R3 represents a methyl group having alpha - or beta -configuration; one of Ra and Rb represents a hydroxy group or protected hydroxy group and the other represents a hydrogen atom; Y represents a valence bond or an alkylene group containing up to 3 carbon atoms; and A= represents a cyclohexylidene moiety characteristic of the A-ring of a 1 alpha -hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit separation of cell modulating and calcaemic activities coupled with enhanced duration of activity. |
