| 摘要 |
The present invention relates to carbapenems and provides a compound of the formula (I) <IMG> (I) wherein R1 is hydroxymethyl, 1-hydroxyethyl or 1-fluoroethyl; R2 is hydrogen or C1-4alkyl; X1 is oxygen or sulphur; and A is of the formula <IMG> which is optionally substituted on either ring and wherein B is of the formula -CH2-C(=O)-(CH2)n-, -C(=O)-(CH2)n1-, -C(=O)-CH=CH-X2-, -C(=O)CH2CH2X2-, -(CH2)nC(=O)NH- or -CH=CHC(=O)NH- wherein n is 1 or 2, n1 is 2 or 3 and X2 is NH, O or S; and a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
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