| 摘要 |
Calixarene derivatives, their synthesis and use as chloride channel blockers are described. Preferred calixarene derivatives are of the formula: <IMAGE> wherein R is an acidic group or salt thereof, such as SO3X or R1SO3X where X is H or Na, and R1 is <IMAGE> where m=1-2, and R3 and R4 the same or different is each H or a C1-4 alkyl, or a nitrogen-containing group of the formula <IMAGE> or A, wherein R5 is a C1-4 alkyl, R6 is a C1-4 alkyl and A is <IMAGE> <IMAGE> where R7 and R8, the same or different each is H or a C1-4 alkyl, and R9 and R10, the same or different, each is H or a C1-4 alkyl; R' is H or a C1-4 alkyl; and n is an integer of 4-8, preferably 4, 6 or 8.
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