发明名称 |
Werkwijze voor het bereiden van een intraveneus toedienbaar antilichaamhoudend immonoglobulinepreparaat. |
摘要 |
A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation. |
申请公布号 |
NL191670(C) |
申请公布日期 |
1996.02.05 |
申请号 |
NL19790006685 |
申请日期 |
1979.09.06 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT |
发明人 |
DR. MARTHA EIBL;DR. OTTO SCHWARZ;DR. YENDRA LINNAU |
分类号 |
A61K39/395;C07K16/06;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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