Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein.

摘要

Novel peptide and peptide mimetic ligands which act as inhibitors of p34 kinase, p33 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.