发明名称 |
NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
摘要 |
Novel 5HT receptor antagonists of general formula (I) in which Ar1 and Ar2 are an aromatic residue, X is O, NH, CH2O or CH2NH, R1 is hydrogen, a linear or branched alkyl chain comprising 1-6 carbon atoms. The invention also concerns the salts, hydrates, solvates and physiologically acceptable bioprecursors for their therapeutic use, their geometric and optic isomers and their mixtures in all proportions and in racemic form. Also disclosed are methods for the preparation of these novel antagonists, their use as drugs and pharmaceutical compositions comprising them. |
申请公布号 |
WO9602525(A1) |
申请公布日期 |
1996.02.01 |
申请号 |
WO1995FR00975 |
申请日期 |
1995.07.20 |
申请人 |
PIERRE FABRE MEDICAMENT;HALAZY, SERGE;JORAND, CATHERINE;PAUWELS, PETER |
发明人 |
HALAZY, SERGE;JORAND, CATHERINE;PAUWELS, PETER |
分类号 |
C07D295/16;A61K31/425;A61K31/426;A61K31/44;A61K31/4402;A61K31/4409;A61K31/495;A61P25/00;C07D213/38;C07D275/02;C07D277/20;C07D277/32;C07D295/185;C07D295/205;C07D295/215;C07D317/66;C07D319/18 |
主分类号 |
C07D295/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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