| 摘要 |
The invention is a peptide of general formula (I) X-Tyr-Y-Phe-Z-A, wherein: X represents H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, Har, D-Har, Cyt, D-Cyt; Y represents D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, DThr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Har, D-Arg, D-His, D-Asp, D-Glu, D-.beta.-Ala, D-Orn; Z represents Ala, D-Ala, Val, D-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gly, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, .beta.-Ala, D-.beta.-Ala, Orn, D-Orn; and A represents OH or a substituted amide (C1-C3). According to the invention, the proposed peptide of general formula (I) is obtained by the gradual construction of a peptide chain, starting from C-terminated amino acid Z, in the form of a substituted amide or carboxyl-protected group, by addition using the method of activated ethers or mixed anhydrides of a successive N-protected amino acid; the N-protective group is split off and the successive N-protected amino acid is re-added to produce a tetra- or pentapeptide which is unblocked in the presence of a palladium catalyst, and the target product is separated out. The proposed peptide and a compound based on it can be used as an agent with pronounced opiate-like properties and also has anabolic properties which increase body weight as well as promoting activity in the growing zones and development of the epidermal layer including the hair. The bio-stimulating properties of the claimed peptide are also evident in the healing of wounds and repair processes.
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