QUINOLINE DERIVATIVES AS LEUKOTRIENE ANTAGONISTS

摘要

The present invention relates to hitherto unknown compounds of formula (I), in which X1 and X2 independently of each other stand for hydrogen or halogen; X3 and X4 independently of each other stand for hydrogen, halogen, nitro, cyano, trifluoromethyl, C1-C4 alkyl, C1-C4 alkoxy, carboxy or C1-C4 carbalkoxy; Z is a bond, O, S, S(O), S(O)2, NH or CH2; R1 is hydrogen or a straight or branched, saturated or unsaturated C1-C6 hydrocarbon chain; R3 is hydrogen, straight or branched, saturated or unsaturated C1-C12 hydrocarbon chain, unsubstituted or substituted phenyl or unsubstituted or substituted benzyl, the above mentioned substituents being one or more of X3 and X4 as defined above; or the group R1-[C]p-R3 stands for cyclopropyl; p may be 0 provided that Z is a bond, or p may be an integer from 1-6 if R1 = R3 = hydrogen; A is COOR2 or 1H-1,2,3,4-tetrazole in which R2 = R1 as defined above or R2 is a pharmaceutically acceptable cation. The present compounds are of value in the human and veterinary practice as leukotrien antagonists.