发明名称 |
Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
摘要 |
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter. |
申请公布号 |
AU666128(B2) |
申请公布日期 |
1996.02.01 |
申请号 |
AU19920025059 |
申请日期 |
1992.08.21 |
申请人 |
ALBERTA RESEARCH COUNCIL;BAPTIST MEDICAL CENTER OF OKLAHOMA, INC. |
发明人 |
A. HEATHER GOOD;DAVID K. C. COOPER;ANDREW J. MALCOLM |
分类号 |
A61K35/12;A61K35/14;A61K39/00;A61M1/36;A61P37/00;(IPC1-7):A61K31/70;A61K31/735;A61K31/73;C07H13/04;C07H3/06 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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