METHODS OF PROGNOSING THE COURSE AND DEGREE OF DEMENTIA IN PATIENTS WITH BETA-AMYLOID-RELATED DISEASES

摘要

A method of prognosing in a subject for the course and nature of disease progression and the ultimate degree of dementia which a subject would suffer during a beta amyloid-related disease, wherein the presence of an ApoE2 isoform or DNA in a subject at risk of such disease or suspected of having such a disease or in the early stages of such a disease indicates that the subject is likely to have a milder, more benign course of disease with the extent of the eventual cognitive impairment or dementia being of mild or moderate degree, the method comprising detecting the presence or absence of ApoE isoforms or of DNA encoding ApoE isoforms in the subject.