Nucleic acid multimers and amplified nucleic acid hybridization assays using same

摘要

Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labelled oligonucleotide. Amplified sandwich nucleic acid hybridization and immunoassays using the multimers are exemplified.