Assay to determine the sensitivity to activated protein C.

摘要

An improved assay to determine sensitivity to activated protein C in assay samples has been developed in order to ensure rapid and accurate analyses. This assay is based on measurement of the conversion of added factor X into an activated form by activated factor VIII within an assay sample. The sensitivity of the assay sample to activated protein C is determined from the relative inhibition of the factor X conversion by comparison with a control. An assay sample with reduced sensitivity to activated protein C shows a relatively low inhibition and vice versa.