| 摘要 |
<p>PCT No. PCT/SE91/00797 Sec. 371 Date Jul. 24, 1992 Sec. 102(e) Date Jul. 24, 1992 PCT Filed Nov. 25, 1991 PCT Pub. No. WO92/09615 PCT Pub. Date Jun. 11, 1992Support system for the synthesis of oligonucleotides wherein the first nucleoside is bound to the support via a silylether linkage, especially of the formula <IMAGE> wherein B is a nucleoside or deoxynucleoside base. R1 is a protecting group. R2 is -H, -OH, or -OR5, in which R5 is a protecting group. R3, R4 and X each represent alkyl, aryl, cycloalkyl, alkenyl, aralkyl, cycloalkylalkyl, alkyloxy, aryloxy, cycloalkyloxy, alkenyloxy, aralkyloxy. S is a solid support, whereby not more than one of R3, R4 and X represent alkyloxy, aryloxy, cycloalkyloxy, alkenyloxy, aralkyloxy or cycloalkylalkyloxy.</p> |
