发明名称 |
USE OF INTERLEUKIN-10 IN ADOPTIVE IMMUNOTHERAPY OF CANCER. |
摘要 |
<p>A method is provided for using interleukin-10 in adoptive immunotherapy of cancer. A population of tumor-infiltrating lymphocytes (TILs) are expanded in culture in the presence of interleukin-2 (IL-2) and interleukin-10 (IL-10). After administration of the TILs to a patient, effective amounts of both IL-2 and IL-10 are administered to enhance the tumor-cell cytoxicity of the TILs and to reduce side-effects caused by IL-2-induced cytokine production in the TILs and other cells of the patient.</p> |
申请公布号 |
GR3017597(T3) |
申请公布日期 |
1996.01.31 |
申请号 |
GR19950402710T |
申请日期 |
1995.10.02 |
申请人 |
SCHERING CORPORATION |
发明人 |
HSU, DI-HWEI;MOORE, KEVIN, W.;SPITS, HERGEN |
分类号 |
A61K38/00;A61K35/14;A61K38/20;A61P35/00;C07K14/05;C07K14/54;C12N5/0783;(IPC1-7):A61K38/20;C12N5/08 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|