| 发明名称 |
HEPATITIS B VACCINE. |
| 摘要 |
<p>A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified a determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as it is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.</p> |
| 申请公布号 |
GR3017804(T3) |
申请公布日期 |
1996.01.31 |
| 申请号 |
GR19950402907T |
申请日期 |
1995.10.18 |
| 申请人 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE |
发明人 |
THOMAS, HOWARD, CHRISTOPHER;CARMAN, WILLIAM, FREDERICK |
| 分类号 |
A61K39/29;A61K31/00;A61K31/711;A61K39/00;A61K39/385;A61K39/395;A61P31/00;A61P31/12;A61P31/20;C07K14/00;C07K14/02;C07K14/10;C07K14/18;C07K14/705;C07K16/00;C07K16/08;C12N1/19;C12N15/09;C12N15/51;C12P21/02;C12P21/08;C12R1/865;G01N33/53;G01N33/576;(IPC1-7):C07K14/02 |
主分类号 |
A61K39/29 |
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