| 摘要 |
Compounds having the structure <IMAGE> (Ia) or <IMAGE> (Ib) wherein (Z-COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, -COO-alkyl, -COO-aryl, -COO-aralkyl, -CO-alkyl, -CO-aryl, -CO-heterocyclyl, cyano or heterocyclyl; R5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2-CR1R2 (CR3R4)n group, wherein Z, R1, R2, R3, R4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m+p>/=1 are useful as contrast agents in x-ray imaging compositions and methods.
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