发明名称 |
Synthesis of compounds with predetermined chirality |
摘要 |
A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.
|
申请公布号 |
US5488131(A) |
申请公布日期 |
1996.01.30 |
申请号 |
US19940216926 |
申请日期 |
1994.03.23 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
MYERS, ANDREW G. |
分类号 |
C07D521/00;B01J31/02;C07B53/00;C07C29/00;C07C29/147;C07C31/10;C07C31/125;C07C33/18;C07C33/34;C07C45/41;C07C45/45;C07C45/67;C07C47/02;C07C47/228;C07C49/04;C07C49/213;C07C49/76;C07C49/782;C07C51/06;C07C53/126;C07C57/30;C07C227/18;C07C227/32;C07C231/12;C07C231/18;C07C233/17;C07C233/18;C07C233/22;C07C235/02;C07C235/34;C07C237/06;C07C237/16;C07C271/22;C07F7/18;C07F9/50;(IPC1-7):C07C271/00;C07C233/04 |
主分类号 |
C07D521/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|