| 摘要 |
The present invention relates to a method of promoting bone repair in human or veterinary medicine; which method comprises the administration of therapeutically effective amounts of bisphosphonic acid derivatives of formula (I): <IMAGE> (I) in which: R1 is a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono-C1-C4-alkylamino or a di-C1-C4-alkylamino; and R2 is a halogen atom or a linear alkyl containing from 1 to 5 carbon atoms which is unsubstituted or substituted by a group selected from a chlorine atom, a hydroxyl, an amino, a mono-C1-C4-alkylamino, a di- C1-C4-alkylamino and a C3-C7-cycloalkylamino, or R2 is a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridylmethyl, a 1-pyridyl-1-hydroxymethyl, an imidazolylmethyl or a thiomorpholin-4-yl; and of their salts with pharmaceutically acceptable mineral or organic acids.
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