7-o-Ethers of taxane derivatives

摘要

The present invention concerns taxane derivatives of formula I, wherein R<1> is hydrogen, C1-8 alkyloxy, C2-8 alkenyloxy, or C2-8 alkynyloxy, each can be optionally substituted with hydroxy; R is hydroxy, -OC(O)R or -OC(O)OR; R<4> and R<5> are independently C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, or -Z-R<6>; p is zero or one; Z is a direct bond, C1-8 alkylene or C2-8 alkenediyl; R<6> is aryl, substituted aryl, C3-8 cycloalkyl or heteroaryl; and R is C1-8 alkyl optionally, substituted with one to six same or different halogen atoms, C3-8 cycloalkyl or C2-8 alkenyl; or R is a radical of the formula wherein D is a bond or C1-8 alkyl; and R, R and R are independently hydrogen, amino, C1-8 alkylamino, di-C1-8alkylamino, halogen, C1-8 alkyl, or C1-8 alkyloxy, their use as antitumor agents and pharmaceutical compositions containing the novel compounds.