DERIVATIVES OF 10,11,12,13-TETRAHYDRODESMYCOSINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS WITH ORGANIC OR INORGANIC ACIDS SHOWING ANTIBACTERIAL ACTIVITY, A METHOD OF SYNTHESIS OF DERIVATIVES OF 10,11,12,13-TETRAHYDRODESMYCOSINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

The invention relates to derivatives of 10,11,12,13-tetrahydro-desmycosin, wherein R stands for O or (OC2H5)2, R<1> stands for Si(CH3)3 or H, R<2> stands for H, OH, I or OSO2CH3, which are novel semisynthetic antibiotics of the tylosin series, possessing antibacterial activity, to their pharmaceutically acceptable salts with inorganic or organic acids, to processes for their preparation and to their use in obtaining pharmaceutical preparations.