发明名称 |
PREPARATION OF PHENYLISOSERINE, LACTAM PRECURSORS |
摘要 |
<p>PCT No. PCT/FR93/00224 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 8, 1993 PCT Pub. No. WO93/17997 PCT Pub. Date Sep. 16, 1993This invention relates to a method for preparing beta -phenylisoserine and analogues thereof having general formula (I) <IMAGE> (I) from an aromatic aldehyde and an alpha -methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of general formula (I) (R=H) may be used to prepare taxane derivatives having remarkable antitumoral and antileukaemic activity.</p> |
申请公布号 |
NZ249899(A) |
申请公布日期 |
1996.01.26 |
申请号 |
NZ19930249899 |
申请日期 |
1993.03.08 |
申请人 |
RHONE-POULENC RORER SA |
发明人 |
BOURZAT, JEAN-DOMINIQUE;COMMERCON, ALAIN |
分类号 |
C07C227/18;C07C227/22;C07C229/34;C07D205/08;C07D305/14;(IPC1-7):C07C229/34 |
主分类号 |
C07C227/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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