摘要 |
Novel imidazole derivatives of the formula <IMAGE> wherein R1, R2, R'1, and R'2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN or halogen; R' is H or <IMAGE> where R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4 and R6 together form a bond or R5 and R7 together form a bond; X and Y, which can be the same or different, are a bond, a straight C1-2-alkyl or the corresponding alkenyl and z is 0 to 2 and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer. |
申请人 |
ORION-YHTYMAE OY |
发明人 |
KARJALAINEN,ARTO JOHANNES;PELKONEN,REINO OLAVI;SOEDERVALL,MARJA-LIISA;LAEHDE,MATTI ANTERO;LAMMINTAUSTA,RISTO ARVO SAKARI;KARJALAINEN,ARJA LEENA;KALAPUDAS,ARJA MARKETTA |