PYRIDO[3,2,1-I,J][3,1]BENZOXAZINE DERIVATIVES

摘要

The present invention relates to novel pyrido¢3,2,1-i,j!¢3,1!benzoxazine derivatives of the formula (I) in which R1 is hydrogen or C1-C4 alkyl possibly substituted by hydroxy or halogen; R2 is hydrogen or methyl independently of R1; R3 is hydrogen or C1-C4 alkyl; R3' is hydrogen or methyl; R4 is hydrogen, alkyl with 1 to 4 carbon atoms, possibly substituted by hydroxy, methoxy, amino, methyl amino or dimethyl amino or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; X1 is hydrogen or halogen; Z is radicals of the structures ((a), (b), (c)) in which R7 is hydrogen, hydroxy, -NR10R11, hydroxy methyl or -CH2-NR10R11, carboxyl, methoxy carbonyl or ethoxy carbonyl, where R10 is hydrogen, possibly hydroxy-substituted C1-C3 alkyl, alkoxy carbonyl with 1 to 4 C atoms in the alkoxy part or C1-C3-acyl, and R11 is hydrogen or methyl; R8 is hydrogen, straight or branched chained C1-C3 alkyl or cyclopropyl; R9 is hydrogen or methyl; R6 is hydrogen or methyl; R5 is hydrogen, methyl or radicals of the structures -CH=CH-CO2R5', -CH2-CH2-CO2R5', -CH2-CO-CH3, -CH2-CH2-CN; R5' is methyl or ethyl; and B is -CH2-, O or a direct bond, their production and use for the therapy or the prevention of bacterial infections.