2-SUBSTITUTED 1,25-DIHYDROXYVITAMIN D3 DERIVATIVES

摘要

Vitamin D3 analogues which include a 2-substituted alcohol or fluoride are described. The preferred alcohol substituent is exemplified by the structural formula -(CH2)4OH and the preferred fluoride substituents by the structural formulas -(CH2)3F and -(CH2)4F. Methods for the preparation of a vitamin D3 analogue which includes a 2-substituted alcohol or fluoride starting with 2+4-cycloaddition of commercially available methyl 2-pyrone-3-carboxylate are also described.