| 摘要 |
<p>The invention is concerned with the compounds having formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R?1, R2 and R3¿ each independently are hydrogen or C¿1-4?alkyl; R?4 and R5¿ each independently are hydrogen, halo, C¿1-4?alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R?6¿ is C¿1-4?alkyl; C1-4alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C1-4alkyl; Z is C=O or CHOH; and (1) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.</p> |
