USE OF SWINHOLIDE A FOR SEVERING AND DEPOLYMERIZING ACTIN

摘要

The present invention provides a method of severing and depolymerizing filamentous actin involving the use of the marine product Swinholide A. This invention also provides methods of treating mammals afflicted with conditions or diseases involving pathological extra cellular actin, in particular with respiratory conditions or diseases where filamentous actin contributes to pathologically high viscosities of the mucous or sputum in the lungs of those mammals.