发明名称 |
Prodrugs of 5,5-diphenylhydantoin as antiepileptic and antiarrhythmic agents |
摘要 |
The present invention deals with a product with the formula (I) which is a new prodrug of phenytoin, as well as its therapeutically acceptable solvates and addition salts. This product shows a solubility significantly higher than phenytoin itself. In addition, surprisingly, its hydrolisis rate is far higher than that of other known prodrugs of phenytoin, making it particularly useful as antiepileptic and antiarrhythmic agent. <CHEM> |
申请公布号 |
EP0693481(A1) |
申请公布日期 |
1996.01.24 |
申请号 |
EP19950500085 |
申请日期 |
1995.06.14 |
申请人 |
LABORATORIOS RUBIO, S.A. |
发明人 |
ROCA ESTREM, TOMAS, LABORATORI DE QUIMICA ORGANICA;BOSCH CARTES, JOAN, LABORATOR. DE QUIMICA ORGANICA;DOMENECH BERROZPE, JOSEP, DEPARTAMENT DE FARMACIA;OBACH VIDAL, ROSSEND, DEPARTEMENT DE FARMACIA;RUBIO ZURITA, PELAYO |
分类号 |
C07D233/74;A61K9/08;A61K31/415;A61K31/4166;A61K31/495;A61K31/535;A61P9/06;A61P25/08;C07D233/72;C07D403/12 |
主分类号 |
C07D233/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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