| 摘要 |
<p>PURPOSE:To industrially advantageously obtain the subject intermediate, e.g. a synthetic raw material for active vitamin D3s by reducing a specific alkenyl halide compound derived from propargyl alcohol using 0 valent palladium catalyst. CONSTITUTION:p-Methoxybenzylpropagyl ether obtained by protecting hydroxyl group of propargyl alcohol is subjected to lithium acetylide-forming reaction and the reactional product is reacted with epichlorohydrin and further, reacted with t-butyldiphenylsilyl-propargyl ether to afford a compound of formula I (MPM is p-methoxybenzyl; TBDPS is t-butyldiphenylsilyl). Then, hydroxyl group of the compound is protected and either one alkynyl group is reduced and transferred and halogenated with iodine, etc., to give a compound expressed by formula II (X is a halogen; R1 and R2 are each a protecting group) and then, the compound is reduced using 0 valent palladium catalyst to industrially advantageously provide the objective vitamin synthetic intermediate expressed by formula III.</p> |
