Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives

摘要

This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula I: <IMAGE> I wherein X is -(CH2)n- or -C(R1)(H)-; R is C1-C8 alkyl; and R1 and R2 are the same or different and are selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8) alkynyl, aryl and benzyl. These compounds are useful to treat central nervous system disorders and are unexpectedly resistant to metabolism by the liver and have superior oral plasma bioavailability.