发明名称 |
Tissue plasminogen activator analogs having modified growth factor domains |
摘要 |
Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along With a physiologically acceptable carrier or diluent are also disclosed.
|
申请公布号 |
US5486471(A) |
申请公布日期 |
1996.01.23 |
申请号 |
US19950400136 |
申请日期 |
1995.03.06 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
MULVIHILL, EILEEN R.;YOSHITAKE, SHINJI;IKEDA, YASUNORI;SUZUKI, SUGURU;HASHIMOTO, AKIRA;YUZURIHA, TERUAKI;NEXO, BJORN A. |
分类号 |
A61K38/00;C12N;C12N9/72;(IPC1-7):C12N9/64;C12N1/21;C12N5/10;A61K38/49 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|