Processes for production of quinoline or quinazoline derivatives and intermediates therefor

摘要

PCT No. PCT/JP95/01210 Sec. 371 Date Sep. 26, 1995 Sec. 102(e) Date Sep. 26, 1995 PCT Filed Jun. 19, 1995 PCT Pub. No. WO96/00223 PCT Pub. Date Jan. 4, 1996Processes for production of quinoline or quinazoline derivatives and intermediates therefor +TR A process for producing a compound of formula (2) of value as antiinflammatory agents, which comprises reacting a compound of formula (3) or a salt thereof with 4-amino-1,2,4-triazole to give a compound of formula (1) or a salt thereof and deaminating the same, and an intermediate compound (1). In the above formulas, Y represents N or C-G in which G represents carboxyl which may be esterified or amidated, acyl, hydroxyalkyl which may be protected, or halogen; ring A and ring B each may be substituted; k is equal to 0 or 1; X represents a leaving group.