发明名称 |
Iontophoretic sampling device and method |
摘要 |
An iontophoresis apparatus for the transdermal monitoring of a target substance comprising: first and second collection reservoirs, the first collection reservoir comprising a first ionically conductive medium (111) and the second collection reservoir comprising a second ionically conductive medium (113); a first iontophoresis electrode (162) in contact with the first conductive medium (111) and a second iontophoresis electrode (164) in contact with the second conductive medium (113); a sensor for detecting the target substance contained within at least one conductive medium (111, 113); and an iontophoretic power source (224). The conductive medium (111, 113) is either an ionically conductive hydrogel or a wicking material containing an ionically conductive medium. The invention also includes a collection reservoir for use with an iontophoresis apparatus for the transdermal monitoring of a target substance, the collection reservoir comprising an ionically conductive hydrogel having a pH in the range of from about 4.0 to about 10.0 and an enzyme reactive with the target substance. The invention also includes a method for using the transdermal monitoring apparatus. In particular, the invention is a method for continuous in vivo monitoring of the blood glucose level of a patient comprising the following steps: (a) placing a collection reservoir on a collection site on a tissue surface of the patient; (b) applying electrical energy to the collection site to move glucose or a glucose metabolite into the collection reservoir; (c) analyzing the collection reservoir for concentration of glucose or glucose metabolite; (d) correlating the concentration determined in step (c) with blood glucose level; and (e) performing steps (a)-(d) substantially continuously. <IMAGE> |
申请公布号 |
AU2944995(A) |
申请公布日期 |
1996.01.19 |
申请号 |
AU19950029449 |
申请日期 |
1995.06.23 |
申请人 |
CYGNUS THERAPEUTIC SYSTEMS |
发明人 |
JANET TAMADA;NOOSHIN T AZIMI;LEWIS LEUNG;RICHARD K-T LEE;PHILLIP J PLANTE;BHASKAR V BHAYANI;MICHAEL CAO;MICHAEL J TIERNEY;PREMA VIJAYAKUMAR |
分类号 |
G01N33/483;A61B5/00;A61B5/145;A61B5/1455;A61B5/1459;A61B5/1473;A61B5/1477;A61B5/1495;A61N1/30;G01N27/04;G01N27/416;G01N27/42;G01N30/88;G01N33/66 |
主分类号 |
G01N33/483 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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