| 摘要 |
Experimental data in the past years in immunology showed that the thymus plays an important role in the selection and development of thymocytes and in the surveillance of "healthy" self cells of the body. Xenotransplantation (xenogeneic transplantation), surveillance and elimination of tumour cells, HIV infection and immune suppression and auto reactive cells in auto immunity are related to thymus and to the development, "education" or maturation of thymocytes. The four projects described in this patent are novel methodological applications that are based on the central immunological role of the thymus and of the thymocytes in immune tolerance, in surveillance of cancer cells, in allogeneic tolerance and in the escape of auto reactive T cells in auto immune disease. Using different approaches targeted on the thymus activity - depending on the clinical condition - by restoring, suppressing, enhancing or by-passing this organ, therapeutical effects are aimed in clinical transplantation, cancerology, infectious diseases and auto immune disease.
|
