摘要 |
The present invention relates to novel pyrido[3,2,1-i,j][3,1]benzoxazine derivatives of the formula (I) in which R<1> is hydrogen or C1-C4 alkyl possibly substituted by hydroxy or halogen; R<2> is hydrogen or methyl independently of R<1>; R<3> is hydrogen or C1-C4 alkyl; R<3'> is hydrogen or methyl; R<4> is hydrogen, alkyl with 1 to 4 carbon atoms, possibly substituted by hydroxy, methoxy, amino, methyl amino or dimethyl amino or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; X<1> is hydrogen or halogen; Z is radicals of the structures ((a), (b), (c)) in which R<7> is hydrogen, hydroxy, -NR<10>R<11>, hydroxy methyl or -CH2-NR<10>R<11>, carboxyl, methoxy carbonyl or ethoxy carbonyl, where R<10> is hydrogen, possibly hydroxy-substituted C1-C3 alkyl, alkoxy carbonyl with 1 to 4 C atoms in the alkoxy part or C1-C3-acyl, and R<11> is hydrogen or methyl; R<8> is hydrogen, straight or branched chained C1-C3 alkyl or cyclopropyl; R<9> is hydrogen or methyl; R<6> is hydrogen or methyl; R<5> is hydrogen, methyl or radicals of the structures -CH=CH-CO2R<5'>, -CH2-CH2-CO2R<5'>, -CH2-CO-CH3, -CH2-CH2-CN; R<5'> is methyl or ethyl; and B is -CH2-, O or a direct bond, their production and use for the therapy or the prevention of bacterial infections.
|
申请人 |
BAYER AG, 51373 LEVERKUSEN, DE |
发明人 |
HALLENBACH, WERNER, DR., 40789 MONHEIM, DE;HIMMLER, THOMAS, DR., 51519 ODENTHAL, DE;JAETSCH, THOMAS, DR., 50668 KOELN, DE;MIELKE, BURKHARD, DR., 51375 LEVERKUSEN, DE;BREMM, KLAUS-DIETER, DR., 45661 RECKLINGHAUSEN, DE;ENDERMANN, RAINER, DR., 42113 WUPPERTAL, DE;PIRRO, FRANZ, DR., 35392 GIESSEN, DE;STEGEMANN, MICHAEL, DR., 51381 LEVERKUSEN, DE;WETZSTEIN, HEINZ-GEORG, DR., 51377 LEVERKUSEN, DE |