摘要 |
Prodn. of N-acyl glycine derivs. of formula (I) comprises (a) reacting a carboxamide of formula (II) with an aldehyde of formula (III) in the presence of a solvent and an acid to form an acylaminomethanol deriv. of formula (IV), and (b) carbonylating (IV) in the presence of a Co carbonyl catalyst at 20-150 deg. C and a CO pressure of 1-150 bar. R1 = H, linear, branched or cyclic 1-26C alkyl, mono- or polyunsaturated linear, branched or cyclic 2-24C alkenyl, 6-18C aryl, (1-10C)alkyl(6-18C) aryl or opt. polyunsaturated (1-10C)alkenyl(6-18C)aryl; R2 = H, linear, branched or cyclic 1-26C alkyl, mono- or polyunsaturated linear, branched or cyclic 2-23C alkenyl, 6-18C aryl, (1-10C)alkyl(6-18C)aryl or opt. polyunsaturated (2-10C)alkenyl(6-18C)aryl; R3 = H, linear branched or cyclic 1-10C alkyl, mono- or polyunsaturated linear, branched or cyclic 2-10C alkenyl, 6-18C aryl, (1-10C)alkyl(6-18C)aryl or opt. polyunsaturated (2-10C)alkenyl(6-18C)aryl. |