| 发明名称 |
GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN THERAPY |
| 摘要 |
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells. |
| 申请公布号 |
EP0692029(A1) |
申请公布日期 |
1996.01.17 |
| 申请号 |
EP19930900818 |
申请日期 |
1992.12.04 |
| 申请人 |
ME MEDICAL ENZYMES AG |
发明人 |
ROBERTS, JOSEPH;MACALLISTER, THOMAS W.;SETHURAMAN, NATARAJAN;FREEMAN, ABBIE G. |
| 分类号 |
C12N15/09;C12N15/55;A61K9/127;A61K35/74;A61K38/00;A61K38/46;A61K39/395;A61K47/48;A61K48/00;A61P31/12;A61P35/00;C07H21/04;C07K14/00;C07K14/21;C07K16/30;C07K19/00;C12N1/21;C12N9/80;C12N9/82;C12R1/19;C12R1/38;(IPC1-7):C12N15/55 |
主分类号 |
C12N15/09 |
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