发明名称 |
Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation |
摘要 |
The present invention provides a compound of formula I <IMAGE> I wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl) or -OSO2(C4-C6 alkyl); n is 2 or 3; and R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof, for inhibiting aortal smooth muscle cell proliferation.
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申请公布号 |
US5484796(A) |
申请公布日期 |
1996.01.16 |
申请号 |
US19950426770 |
申请日期 |
1995.04.21 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BRYANT, HENRY U.;CULLINAN, GEORGE J.;DODGE, JEFFREY A.;FAHEY, KENNAN J.;JONES, CHARLES D.;LUGAR, CHARLES W.;MUEHL, BRIAN S. |
分类号 |
C07D295/08;A61K31/13;A61K31/135;A61K31/40;A61K31/445;A61K31/4453;A61K31/535;A61K31/5375;A61K31/55;A61P3/02;A61P3/06;A61P13/02;A61P15/00;A61P15/12;A61P19/10;A61P35/00;A61P43/00;C07C211/19;C07C213/08;C07C217/18;C07C303/26;C07C309/65;C07D207/06;C07D207/08;C07D211/22;C07D295/088;C07D295/092;(IPC1-7):A61K31/445;C07D211/06;C07D211/20 |
主分类号 |
C07D295/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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