THE USE OF ISOLATED DOMAINS OF TYPE IV COLLAGEN TO MODIFY CELL AND TISSUE INTERACTIONS
摘要
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.
申请公布号
WO9600582(A1)
申请公布日期
1996.01.11
申请号
WO1995US08299
申请日期
1995.06.30
申请人
UNIVERSITY OF KANSAS MEDICAL CENTER;SARRAS, MICHAEL, P., JR.;HUDSON, BILLY, G.