| 发明名称 |
NEW BREFELDIN A DERIVATIVES AND THEIR UTILITY IN THE TREATMENT OF CANCER |
| 摘要 |
Provided are brefeldin A derivatives of formula (II), wherein one of R1 and R2 is H and the other of R1 and R2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
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| 申请公布号 |
CA2193704(A1) |
申请公布日期 |
1996.01.11 |
| 申请号 |
CA19952193704 |
申请日期 |
1995.06.29 |
| 申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY, THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (THE) |
发明人 |
MALSPEIS, LOUIS;VISHNUVAJJALA, B. RAO;SUPKO, JEFFREY G.;KANE, CHARLES T., JR. |
| 分类号 |
A61K31/365;A61P35/02;C07D313/00;(IPC1-7):C07D313/00;C07D405/12;C07D413/12;C07D417/12;C07D419/12;A61K31/395 |
主分类号 |
A61K31/365 |
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