发明名称 |
Nonpeptide endothelin antagonists |
摘要 |
Novel indole and indoline nonpeptide antagonists of endothelin I are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure and subarachnoid hemorrhage.
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申请公布号 |
US5482960(A) |
申请公布日期 |
1996.01.09 |
申请号 |
US19940339381 |
申请日期 |
1994.11.14 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
BERRYMAN, KENT A.;BUNKER, AMY M.;DOHERTY, ANNETTE M.;EDMUNDS, JEREMY J. |
分类号 |
C07D491/113;A61K31/40;A61K31/403;A61K31/404;A61K31/415;A61P9/00;A61P11/00;A61P43/00;C07D209/42;C07D405/04;C07D405/06;C07D405/14;C07D491/056;(IPC1-7):A61K31/40;C07D209/04 |
主分类号 |
C07D491/113 |
代理机构 |
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代理人 |
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地址 |
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