| 摘要 |
Novel 2,9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-ones having the formula <IMAGE> (I) the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein Alk represents C1-4alkanediyl, D is a bicyclic heterocycle of formula <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) wherein R1 represents C1-4alkyl, hydroxyC1-4alkyl, carboxaldehyde, carboxyl, C1-10alkylcarbonyloxyC1-4alkyl; each R2 represents hydrogen or C1-4alkyl; R3 represents C1-4alkyl, hydroxyC1-4alkyl or methyl substituted with phenyl, 5-methyl-2-furanyl or 3-pyridinyl; and R4 represents C1-3alkyl, phenyl, 5-methyl-2-furanyl or 3-pyridinyl.
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